Methotrexate 50mg Injection

Indications of Methotrexate 50mg Injection:

Cancer treatment, including:

• Acute lymphoblastic leukemia (ALL)
• Non-Hodgkin’s lymphoma
• Osteosarcoma
• Breast, lung, head and neck cancers
• Other solid tumors as per oncology protocols

• Supportive therapy in autoimmune diseases (at different dosing schedules), such as severe psoriasis or rheumatoid arthritis, when oral forms are not suitable

Administration of Methotrexate 50mg Injection:

• Given as an intravenous (IV) or intramuscular (IM) injection under strict medical supervision
• Dosage depends on the type of cancer, treatment regimen, and patient body surface area
• In high-dose methotrexate therapy, Leucovorin (Folinic acid) rescue is required to protect healthy cells
• Adequate hydration and urine alkalinization may be necessary to reduce toxicity

Safety Information:

• Contraindicated in pregnancy, breastfeeding, severe liver or kidney disease, and pre-existing bone marrow suppression
• Common side effects: nausea, vomiting, mouth sores, fatigue, low blood counts, hair loss
• Serious risks: severe bone marrow suppression, liver toxicity, kidney failure, lung inflammation, gastrointestinal ulceration
• Requires regular monitoring of blood counts, liver and kidney function
• Can interact with several medicines (e.g., NSAIDs, antibiotics, and other cytotoxic drugs)
• Effective contraception must be used during and after treatment

Notice:
Methotrexate Injection is a prescription-only cytotoxic medicine. It must be prepared and administered in a hospital or oncology setting by trained healthcare professionals.