Indication
Zithrox is used in reatment of susceptible bacterial infections, including:
- Acute bacterial sinusitis/otitis media
- Pharyngitis/tonsillitis
- Acute exacerbation of chronic bronchitis
- Mild to moderate community-acquired pneumonia
- Skin/soft tissue infections (e.g., cellulitis, erysipelas)
- Uncomplicated Chlamydia trachomatis urethritis/cervicitis
Dosage
Adults:
Uncomplicated Chlamydia infections: Single 1g dose (two 500mg tablets taken at once).
Other infections: Typically 500mg once daily for 3 days (varies by infection severity and type). Always follow a healthcare provider’s prescription.
Children; Dosage is determined according to weight and the type of infection
Side Effects
Common side effects include: Gastrointestinal (nausea, diarrhea, abdominal pain),headache, dizziness,rash
Serious (rare) side effects include: Liver dysfunction, arrhythmias, severe allergic reactions
Precautions
Zithrox is contraindicated in patients who are hypersensitivity to macrolides.
- Use cautiously in patients with liver/kidney impairment.
- Avoid prolonged use to prevent antibiotic resistance.
- Monitor for Clostridioides difficile-associated diarrhea.
Interactions
- Antacids reduces absorption of azithromycin and shoud be given atleast 2 hours a part.
- Warfarin may enhance anticoagulant effect thus monitor INR is required with concommitant use.
- Digoxin & statins concommitant use with azithromycin may rincrease risk of toxicity.
